Contrasting Orphazyme A/S (NASDAQ:ORPH) and TherapeuticsMD (NASDAQ:TXMD)

Orphazyme A/S (NASDAQ:ORPH) and TherapeuticsMD (NASDAQ:TXMD) are both small-cap medical companies, but which is the superior business? We will compare the two companies based on the strength of their profitability, dividends, risk, analyst recommendations, institutional ownership, valuation and earnings.

Insider and Institutional Ownership

10.6% of Orphazyme A/S shares are owned by institutional investors. Comparatively, 52.6% of TherapeuticsMD shares are owned by institutional investors. 13.8% of TherapeuticsMD shares are owned by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term.


This table compares Orphazyme A/S and TherapeuticsMD’s net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Orphazyme A/S N/A N/A N/A
TherapeuticsMD -327.98% N/A -78.47%

Earnings and Valuation

This table compares Orphazyme A/S and TherapeuticsMD’s revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Orphazyme A/S N/A N/A N/A N/A N/A
TherapeuticsMD $49.65 million 9.74 -$176.15 million ($0.68) -1.81

Orphazyme A/S has higher earnings, but lower revenue than TherapeuticsMD.

Analyst Ratings

This is a breakdown of current recommendations and price targets for Orphazyme A/S and TherapeuticsMD, as reported by MarketBeat.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Orphazyme A/S 1 0 1 0 2.00
TherapeuticsMD 1 1 3 0 2.40

Orphazyme A/S currently has a consensus price target of $16.00, suggesting a potential upside of 65.12%. TherapeuticsMD has a consensus price target of $5.07, suggesting a potential upside of 311.92%. Given TherapeuticsMD’s stronger consensus rating and higher probable upside, analysts clearly believe TherapeuticsMD is more favorable than Orphazyme A/S.


TherapeuticsMD beats Orphazyme A/S on 6 of the 8 factors compared between the two stocks.

About Orphazyme A/S

Orphazyme A/S, a biopharmaceutical company, develops therapies for the treatment of neurodegenerative orphan diseases. The company focuses on the amplification of heat-shock proteins to develop and commercialize therapeutics for diseases caused by protein misfolding and aggregation, and lysosomal dysfunction, including lysosomal storage and neuromuscular degenerative diseases. Its lead candidate is the Arimoclomol, which is in clinical development for four orphan diseases, including Niemann-Pick disease type C, Amyotrophic Lateral Sclerosis, Inclusion Body Myositis, and Gaucher disease. The company was incorporated in 2009 and is headquartered in Copenhagen, Denmark.

About TherapeuticsMD

TherapeuticsMD, Inc. operates as a women's healthcare company in the United States. The company offers IMVEXXY for the treatment of moderate-to-severe dyspareunia; BIJUVA, a bio-identical hormone therapy combination of 17Ã-estradiol and progesterone for the treatment of moderate-to-severe vasomotor symptoms; and ANNOVERA, a ring-shaped contraceptive vaginal system. Its preclinical projects include the development of TX-005HR, a progesterone-alone transdermal cream; TX-006HR, an estradiol and progesterone transdermal cream; and TX-007HR and TX-008HR, which are transdermal patch product candidates. The company's clinical development product is TX-009HR, an oral progesterone and estradiol formulation. It also manufactures and distributes branded and generic prescription prenatal vitamins under the vitaTrue, vitaPearl, vitaMedMD, and BocaGreenMD Prena1 brands. The company sells its prescription prenatal vitamin and hormone therapy drug products to wholesale distributors and retail pharmacy distributors. TherapeuticsMD, Inc. was founded in 2008 and is headquartered in Boca Raton, Florida.

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